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Hepatosplenomegaly; Enlarged liver; Liver enlargement

Hepatomegaly is the enlargement of the liver beyond its normal size. Hepatosplenomegaly is enlargement of both the liver and the spleen.

The lower edge of the liver normally comes just to the lower edge of the ribs (costal
margin) on the right side. In its normal state, the edge of the liver is thin and firm,
and it cannot be palpated (felt with the finger tips) below the edge of the costal margin.


The liver is involved in a multitude of bodily functions, and is affected by a variety
of conditions, many of which result in hepatomegaly.

Common causes include

  • Alcohol
  • Hepatitis A
  • Hepatitis B
  • Congestive heart failure
  • Infectious mononucleosis
  • Leukemia
  • Tumour metastases
  • Neuroblastoma
  • Hepatocellular carcinoma
  • Niemann-Pick disease
  • Hereditary fructose intolerance
  • Glycogen storage disease
  • Primary biliary cirrhosis
  • Sarcoidosis
  • Sclerosing cholangitis
  • Hemolytic-uremic syndrome (HUS)
  • Reye's syndrome


Your healthcare provider will undertake a medical history and do a physical examination.

There may be more than one diagnostic test to determine the cause of Hepatomegaly
and may include:

  • Abdominal and chest X-ray
  • Ultrasound of the abdomen including the liver
  • CT scan of the abdomen
  • Blood tests, including liver function tests and blood clotting studies

Depends on the cause.

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ANZGOSA - Australia & New Zealand Gastric & Oesophageal Surgery Association Your Practice Online